About the twinkle factory

Our Ambition

Why we’ve decided to gather up in order to invent and provide efficient tools to observe processes that were, so far, invisible.


The Twinkle project

Seeing cellular mechanisms is the first step towards understanding the inner workings of living systems. But, despite dramatic advances in biological imaging and probe design, many relevant biological molecules and processes remain invisible. Therefore, we, at The Twinkle Factory, invent new ways of observing biomolecules and cellular event.  We indeed provide efficient tools to observe previously invisible processes in order to address issues ranging from fundamental mechanisms to causes of disease and the development of new therapies. Discover the science behind the project

Our start-up was born from the ambition of Arnaud Gautier, Ludovic Jullien and Franck Perez, three top-notch scientists from ENS-PSL, the Institut Curie and Sorbonne University, to help others accelerate their research. Read more about us

The Twinkle Factory provides transformative chemical-genetic tools for various applications in biological imaging. These tools are based on the instantaneous formation of a fluorescent molecular assembly between the FAST protein or its derivatives and fluorogenic ligands (TFFluorogens). The latter are dark in water and fluoresce only when bound to FAST, allowing specific detection by fluorimetry or optical microscopy. Know more about our products

We are currently involved in more developments dealing with bioimaging. We are continuously eager to deliver innovative tools enabling end-users to address unprecedented questions. Our goal is to meet a wide range of needs: protein & cell labeling, tunable colors, labeling under anaerobic conditions, cellular dynamics, protein-protein interactions, sensors… Go to the Applications page

Key dates


Publication of the seminal article about FAST in Proceedings of the National Academy of Sciences.


Creation of The Twinkle Factory. Publications about FAST and its extensions in international journals.


First users of the FAST technology start to sprout in the USA, in India, in Germany, in the UK, in Singapore.


Our Partners

The development of The Twinkle Factory was supported by the University PSL, a shareholder, and the Région Ile-de-France, through an INNOV’up subsidy.

The Twinkle Factory

We are a French biotech company that provides ground breaking fluorescent chemical-genetic tools for labelling and imaging



© 2021 Twinkle Bioscience – Paris