Stain different, tag FAST
Stain Different Tag FAST with The Twinkle Factory! This is how everything got started in 2017 from the wish of Arnaud Gautier, Ludovic Jullien and Franck Perez, three top-notch scientists from ENS-PSL, Sorbonne University, and the Institut Curie to help others accelerate their research.
Seeing cellular mechanisms is the first step towards understanding the inner workings of living systems. But many biological molecules and processes are yet to be unveiled. Our research aims at inventing new ways of observing biomolecules and cellular events via next-generation fluorescent labels in cell-based assays, live cell imaging, cytometry.
The Twinkle Factory’s products are based on the instantaneous formation of a fluorescent molecular assembly between the FAST protein or splitFAST and fluorogenic ligands (Fluorogens). Only the assembly of both the tag and the Fluorogen fluoresce, allowing specific detection by fluorimetry or optical microscopy. We hence provide efficient tools for various applications in biological imaging, from fundamental mechanisms to drug screening.
Our latest post
FAST nanoprobes for anaerobic tracking of gut microbiota vesicles
disclosed by School of Medicine, Shanghai Jiao Tong University in ACS Nano
Our earlier posts
The patent application for splitFAST just published by EPO
The EPO has just published the patent application for splitFAST by Prof. Arnaud Gautier and Dr. Alison Tebo
Visualizing bacterial protein export with FAST
Scientific Reports officially announces the union of FAST and Listeria witnessed by Prof. Beloin and Prof. Desprat
The Twinkle Factory launches tfPoppy for far-red labeling
A major addition to The Twinkle Factory’s fluorogen color range at the red end (more to come at the blue end!)
Interspecies cell fusion in anaerobic Clostridium coculture
Beyond syntrophy: in this mBio issue, Prof. Papoutsakis explores anaerobic Clostridium cocultures
Prof. Arnaud Gautier discloses frFAST for far-red labeling
This paper in Angew. Chem. Int. Ed. discloses frFAST and split-frFAST for far-red labeling
Prof. Arnaud Gautier discloses greenFAST and redFAST
This paper in Nature Chemical Biology discloses orthogonal FAST variants for multicolor imaging
Orthogonal multicolor labeling in anaerobic Clostridium
In this Appl. Environ. Microbiol. issue, Prof. Papoutsakis reports a major addition to the genetic toolkit of Clostridium
The Twinkle Factory is rapidly expanding sales worldwide
This video tracks The Twinkle Factory expanding fluorogen sales worldwide since early 2019
The Twinkle Factory in China with Zhengzhou Maxcare Bio
The fluorogens of The Twinkle Factory now readily available in China: no currency exchange, no custom clearance
Prof. Arnaud Gautier discloses FAST of The Twinkle Factory
In this video posted by France Bio-Imaging in 2017, Prof. Arnaud Gautier disclosed FAST of The Twinkle Factory