Stain different, tag FAST
The Twinkle Factory is rooted in the wish of Arnaud Gautier, Ludovic Jullien and Franck Perez, three top-notch scientists of ENS-PSL, Sorbonne University, and Institut Curie to help life science researchers accelerate their work. The Twinkle Factory thus distributes reagents for their breakthrough protein fluorescent reporters and molecular glues, FAST and splitFAST (What is it, FAST and splitFAST?), and CATCHFIRE (What is it, CATCHFIRE?).
It all started in 2019 with a three-item-long pricelist for FAST and splitFAST. Along with cofounders’ research, non-permeant fluorogens, a far-red fluorogen, a fluorescence quencher, have added to the list. As a result, sales rapidly expanded worldwide. So far, 300 research teams at universities, life sciences startups, big pharmas, CROs, have implemented FAST and splitFAST in their research. Their key words are metabolic engineering, microbiota, protein-protein interactions, synthetic biology, cell-based assays, sensors… Furthermore, they unveiled the potential of FAST in hypoxic conditions, equipping a vast array of microorganisms.
And in 2023, we have added a whole range of fluorogenic molecular glues for CATCHFIRE.
This is just the beginning! Actinometers, and many other twinkling reagents are indeed joining the pack. Stay tuned!
Our latest post
Secretory system of Clostridium perfringens with FAST
disclosed by Prof. S. Melville et al. in bioRxiv
Our earlier posts
BRET and FAST are glad to introduce BREAKFAST
disclosed in RSC Chem. Biol. by UC Irvine researchers
One more! FAST in Corynebacterium glutamicum
disclosed in Microb. Cell Fact. by KAIST researchers
Multiplex FLIM with fluorescence lifetime-modulating FAST tags
simultaneously in France and in Russia!
Switchable targeted protein degradation with the help of splitFAST
a preprint by W. Chen & H. Yang of University of Delaware
FAST in Saccharomyces cerevisiae, a routine technique!
by the University of Queensland
GPCR in dendritic spine maturation with splitFAST
by Prof. Joris De Wit of KU Leuven and team
Interferon-inducible MX1 combat against Influenza A elucidated with FAST
by Dr. McKellar of Montpellier University
FAST in Clostridioides difficile for the first time ever
disclosed by Institut Pasteur in PLOS Pathogens
splitFAST2, next-gen splitFAST for membrane contact sites
simultaneously in ACS Chem. Biol. and bioRxiv
Eubacterium strain engineering with FAST: easy, fast!
by Wageningen University’s Dr. Flaiz et al. in Microbial Cell Factories
Endoplasmic reticulum-mitochondria junction studies with splitFAST
by Prof. Pizzo of Padova University
Metabolic engineering in S. cerevisiae with FAST – Cont’d
disclosed by the University of Queensland in ACS Synth. Biol.
Thanks to the continued support of PSL Université and Région Ile-de-France.