Stain different, tag FAST
Stain Different Tag FAST with The Twinkle Factory! This is how everything got started in 2017 from the wish of Arnaud Gautier, Ludovic Jullien and Franck Perez, three top-notch scientists from ENS-PSL, Sorbonne University, and the Institut Curie to help others accelerate their research.
Seeing cellular mechanisms is the first step towards understanding the inner workings of living systems. But many biological molecules and processes are yet to be unveiled. Our research aims at inventing new ways of observing biomolecules and cellular events via next-generation fluorescent labels in cell-based assays, live cell imaging, cytometry.
The Twinkle Factory’s products are based on the instantaneous formation of a fluorescent molecular assembly between the FAST protein or splitFAST and fluorogenic ligands (Fluorogens). Only the assembly of both the tag and the Fluorogen fluoresce, allowing specific detection by fluorimetry or optical microscopy. We hence provide efficient tools for various applications in biological imaging, from fundamental mechanisms to drug screening.
Our latest post
FAST nanoprobes for anaerobic tracking of gut microbiota vesicles
disclosed by School of Medicine, Shanghai Jiao Tong University in ACS Nano
Our earlier posts
FAST and splitFAST, greenFAST & redFAST, pFAST in a nutshell
A review of this exciting journey in Account Chemistry Research by inventor Prof. Arnaud Gautier
FAST and splitFAST to the fore at CLOSTRIDIUM XVI
three talks and one poster disclosing FAST of The Twinkle Factory in acetogenic and solventogenic Clostridia
FAST in archaea imaging: towards a new standard
FAST in anaerobic methanogenic archaea FACSing just reported in bioRxiv by N. Adlung of Uni Aalto
Microbiota in vivo imaging with FAST-encoded bacterial probes
Gut and tumor microbiota in vivo imaging disclosed by a team of the Shanghai Jiao Tong University
FAST and splitFAST in Archaea for the first time ever!
FAST and splitFAST in Archaea just disclosed by Kyle Costa’s lab at University of Minnesota
The Twinkle Factory launches the non-permeant fluorogen tfFox-NP
For protein trafficking / excretion studies – After A. Gautier in Nat. Commun. 2021
The Twinkle Factory launches the dark chromophore tfDarth
For your most demanding multi-step multi-color protocols – after Arnaud Gautier in Nat. Commun. 2021
Speed up lactate-producing strain engineering with FAST
A collaboration of Ulm University and the University of Nottingham published in Applied Microbiology and Biotechnology
greenFAST and redFAST in anaerobes
Towards #CarbonSmart – by M. Flaiz of Ulm University – in ACS Synth. Biol.
Painting with pFAST, a FAST variant, for advanced imaging
In Nat. Commun., Prof. Arnaud Gautier discloses an improved pFAST and a variety of novel fluorogens
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US patent for non-permeant FAST fluorogens just granted
The USPTO has just granted the patent for non-permeant FAST fluorogens by Prof. Arnaud Gautier et al.