Stain different, tag FAST
Stain Different Tag FAST with The Twinkle Factory! This is how everything got started in 2017 from the wish of Arnaud Gautier, Ludovic Jullien and Franck Perez, three top-notch scientists from ENS-PSL, Sorbonne University, and the Institut Curie to help others accelerate their research.
Seeing cellular mechanisms is the first step towards understanding the inner workings of living systems. But many biological molecules and processes are yet to be unveiled. Our research aims at inventing new ways of observing biomolecules and cellular events via next-generation fluorescent labels in cell-based assays, live cell imaging, cytometry.
The Twinkle Factory’s products are based on the instantaneous formation of a fluorescent molecular assembly between the FAST protein or splitFAST and fluorogenic ligands (Fluorogens). Only the assembly of both the tag and the Fluorogen fluoresce, allowing specific detection by fluorimetry or optical microscopy. We hence provide efficient tools for various applications in biological imaging, from fundamental mechanisms to drug screening.
Our latest post
Our earlier posts
Towards C1-based biofuels and chemicals! By R. Hocq of TU Wien
disclosed by School of Medicine, Shanghai Jiao Tong University in ACS Nano
A review of this exciting journey in Account Chemistry Research by inventor Prof. Arnaud Gautier
three talks and one poster disclosing FAST of The Twinkle Factory in acetogenic and solventogenic Clostridia
FAST in anaerobic methanogenic archaea FACSing just reported in bioRxiv by N. Adlung of Uni Aalto
Gut and tumor microbiota in vivo imaging disclosed by a team of the Shanghai Jiao Tong University
FAST and splitFAST in Archaea just disclosed by Kyle Costa’s lab at University of Minnesota
For protein trafficking / excretion studies – After A. Gautier in Nat. Commun. 2021
For your most demanding multi-step multi-color protocols – after Arnaud Gautier in Nat. Commun. 2021
A collaboration of Ulm University and the University of Nottingham published in Applied Microbiology and Biotechnology
Towards #CarbonSmart – by M. Flaiz of Ulm University – in ACS Synth. Biol.
In Nat. Commun., Prof. Arnaud Gautier discloses an improved pFAST and a variety of novel fluorogens