Stain different, tag FAST
Stain Different Tag FAST with The Twinkle Factory! This is how everything got started in 2017 from the wish of Arnaud Gautier, Ludovic Jullien and Franck Perez, three top-notch scientists from ENS-PSL, Sorbonne University, and the Institut Curie to help others accelerate their research.
Seeing cellular mechanisms is the first step towards understanding the inner workings of living systems. But many biological molecules and processes are yet to be unveiled. Our research aims at inventing new ways of observing biomolecules and cellular events via next-generation fluorescent labels in cell-based assays, live cell imaging, cytometry.
The Twinkle Factory’s products are based on the instantaneous formation of a fluorescent molecular assembly between the FAST protein or splitFAST and fluorogenic ligands (Fluorogens). Only the assembly of both the tag and the Fluorogen fluoresce, allowing specific detection by fluorimetry or optical microscopy. We hence provide efficient tools for various applications in biological imaging, from fundamental mechanisms to drug screening.
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Want to try FAST of The Twinkle Factory? Check e-Zyvec, the worldwide expert in FAST vectors, to expedite your research
Sincerely happy to help iGEM teams inventing new tools for tomorrow’s synthetic biology
Want to expedite implementation of frFAST and split-frFAST? Check for plasmids at Addgene
This video tracks The Twinkle Factory expanding fluorogen sales worldwide since early 2019
Decipher Listeria invasion pathways with Prof. Desprat and Dr. Lebreton by means of FAST
The EPO has just published the patent application for splitFAST by Prof. Arnaud Gautier and Dr. Alison Tebo
Scientific Reports officially announces the union of FAST and Listeria witnessed by Prof. Beloin and Prof. Desprat
A major addition to The Twinkle Factory’s fluorogen color range at the red end (more to come at the blue end!)
Beyond syntrophy: in this mBio issue, Prof. Papoutsakis explores anaerobic Clostridium cocultures
This paper in Angew. Chem. Int. Ed. discloses frFAST and split-frFAST for far-red labeling
This paper in Nature Chemical Biology discloses orthogonal FAST variants for multicolor imaging
In this Appl. Environ. Microbiol. issue, Prof. Papoutsakis reports a major addition to the genetic toolkit of Clostridium