Since initial sales in 2019, The Twinkle Factory has been rapidly expanding sales worldwide. Growth drivers are both FAST leveling-up and fluorogen catalog expansion. Prof. Arnaud Gautier, Prof. Ludovic Jullien and Dr. Franck Perez conduct fundamental research at Sorbonne University, ENS and Institut Curie of PSL University. The most noticeable breakthrough was splitFAT published in Nature Communications 2019. splitFAST is indeed a complementation system capable of reporting the most transient protein-protein interactions. Besides, The Twinkle Factory develops a growing catalog of commercial fluorogens for FAST and derivatives. The original catalog comprised of tfLime, tfAmber, and tfCoral. It further added tfAmber-NP, a non-permeant fluorogen for reporting membrane protein trafficking.