Oct 26, 2026 | FAST and splitFAST
A split reporter can tell whether a protein complex has been built, cell by cell. A preprint from Harvard uses splitFAST with TFLime to read out the assembly of cytochrome c oxidase (complex IV) in the mitochondria of living yeast, and the readout helps explain why...
Oct 5, 2026 | FAST and splitFAST
Light can now change the colour of a FAST label, and change it back. A new study shows that FAST tags researchers already use, combined with the right fluorogens, become reversible photoswitches across the whole visible range, and even reversibly photoconvertible...
Sep 28, 2026 | FAST and splitFAST
FLIM-FRET is the most quantitative way to see two proteins come together in a living cell. Its weak spot is the reference: what does “no FRET” look like in that same cell? A new study answers with a FAST acceptor you switch on and off with a fluorogen. The...
Sep 14, 2026 | Catchfire, FAST and splitFAST, The Twinkle Factory
How do you label a protein that you may want to un-label a few seconds later? That question runs through Turning Fluorescence On and Off: Reversible Tags for Live-cell Imaging, an article by Luc Lenglet of The Twinkle Factory, published by Labcompare on 11 September...
Sep 7, 2026 | FAST and splitFAST
A reversible split reporter can tell how long an organelle contact lasts, not just whether it formed. A new study in The Journal of Clinical Investigation used splitFAST with TFLime to count contacts between the endoplasmic reticulum (ER) and mitochondria in live...
Aug 31, 2026 | FAST and splitFAST, Fluorogens
A new fluorogen turns the pFAST tag into a reversible photoswitch, and that opens up imaging you cannot do with an ordinary green label. RSpFAST is not a new tag. It is the pFAST tag paired with a fluorogen that light can flip between two forms. Bound inside pFAST,...
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