Sep 23, 2024 | FAST and splitFAST
BREAKFAST, Bioluminescence Resonance Energy mAKe over with a Fluorescence-Activating absorption-Shifting Tag, they call it. A team of UC Irvine led by Prof. J. Prescher has combined BRET and FAST together into a new customizable platform for in vivo imaging at...
Sep 16, 2024 | FAST and splitFAST, Microbiology
FAST in Corynebacterium glutamicum adds to the long list of microorganisms already FAST-equipped for a variety of purposes: metabolic engineering, screening, virulence mechanism deciphering, etc. Indeed, the team led by Prof. Ki Jun Jeong of KAIST has just disclosed...
Jul 8, 2024 | FAST and splitFAST
The long-awaited FAST tags for multiplex FLIM (Fluorescence Lifetime Imaging Microscopy) are now here! The team led by Arnaud Gautier of Sorbonne University indeed disclosed FAST-based fluorescence lifetime-modulating tags days ago in Adv. Sci. 2024. Those FAST...
Jul 1, 2024 | FAST and splitFAST
W. Chen and H. Yang of University of Delaware have just introduced a bioPROTAC system for logic-gated, switchable targeted protein degradation. With the help of splitFAST and FAST of The Twinkle Factory. BioPROTACs are heterobifunctional proteins designed for...
Jun 3, 2024 | FAST and splitFAST
Remember the metabolic engineering work in S. cerevisiae of the lab of Claudia Vickers from the University of Queensland? In 2021, they disclosed very elegant strategies, e.g., flux redirecting, metabolic modulation. Selective auxin-mediated degradation of essential...
May 13, 2024 | FAST and splitFAST, Mammals
A team led by Prof. Joris De Wit of KU Leuven has just elucidated the role of a special GPCR in dendritic spine maturation with splitFAST of The Twinkle Factory. Synapses, the junctions connecting neurons into neural circuits, are most diverse, morphologically,...
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